New triazole-substituted triterpene derivatives exhibiting anti-RSV activity: synthesis, biological evaluation, and molecular modeling

• Elenilson F. da Silva,
• Krist Helen Antunes Fernandes,
• Denise Diedrich,
• Jessica Gotardi,
• Marcia Silvana Freire Franco,
• Carlos Henrique Tomich de Paula da Silva,
• Ana Paula Duarte de Souza and
• Simone Cristina Baggio Gnoatto

Beilstein J. Org. Chem. 2022, 18, 1524–1531, doi:10.3762/bjoc.18.161

• , University of São Paulo, Ribeirão Preto, SP 14040-020, Brazil 10.3762/bjoc.18.161 Abstract Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infections in infants. Currently, ribavirin, a nucleoside analog containing a 1,2,4-triazole-3-carboxamide moiety, is a first-line

• the same region occupied by crystallographic ligands in their complex with IMPDH. The results obtained in this study suggest that compound 8 might be a new anti-RSV candidate. Keywords: antiviral; betulinic acid; bioisosterism; respiratory syncytial virus; triterpene; ursolic acid; Introduction

• Respiratory syncytial virus (RSV), an enveloped RNA-type virus, usually causes cold-like symptoms and is considered the major cause of acute lower respiratory tract infections (ALRIs) in infants. Until 2019, RSV was a major cause of morbidity in the elderly and immunocompromised people. It has been linked to

Bipolenins K–N: New sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana

• Chin-Soon Phan,
• Hang Li,
• Simon Kessler,
• Peter S. Solomon,
• Andrew M. Piggott and
• Yit-Heng Chooi

Beilstein J. Org. Chem. 2019, 15, 2020–2028, doi:10.3762/bjoc.15.198

• effects on cells infected with respiratory syncytial virus [22][23], induction of aerial mycelium formation in Fusarium culmorum [24], and as an inhibitor of ubiquinol-cytochrome c reductase binding protein, blocking mitochondrial ROS-mediated vascular endothelial growth factor receptor type 2 signalling

Recent advances in synthetic approaches for medicinal chemistry of C-nucleosides

• Kartik Temburnikar and
• Katherine L. Seley-Radtke

Beilstein J. Org. Chem. 2018, 14, 772–785, doi:10.3762/bjoc.14.65

• ), respiratory syncytial virus (RSV, Pneumoviridae) and the hepatitis-C virus (HCV, Flaviviridae) family [63][65][69]. Through structure activity relationship studies, the 1'-CN compound 4 emerged as a compound with activity against EBOV, HCV and RSV [65][69]. It is active against EBOV in human microvascular

Interactions between cyclodextrins and cellular components: Towards greener medical applications?

• Loïc Leclercq

Beilstein J. Org. Chem. 2016, 12, 2644–2662, doi:10.3762/bjoc.12.261

Facile synthesis of 1-alkoxy-1H-benzo- and 7-azabenzotriazoles from peptide coupling agents, mechanistic studies, and synthetic applications

• Mahesh K. Lakshman,
• Manish K. Singh,
• Mukesh Kumar,
• Raghu Ram Chamala,
• Vijayender R. Yedulla,
• Domenick Wagner,
• Evan Leung,
• Lijia Yang,
• Asha Matin and
• Sadia Ahmad

Beilstein J. Org. Chem. 2014, 10, 1919–1932, doi:10.3762/bjoc.10.200

• have been evaluated as inhibitors of respiratory syncytial virus [1], halogenated benzotriazoles have been shown to inhibit helicase activity of hepatitis C [2], N-alkylbenzotriazoles were shown to be active and selective towards HCV NTPase/helicase [3]. Benzotriazoles also possess anti-amoebic

Facile synthesis of benzothiadiazine 1,1-dioxides, a precursor of RSV inhibitors, by tandem amidation/intramolecular aza-Wittig reaction

• Krishna C. Majumdar and
• Sintu Ganai

Beilstein J. Org. Chem. 2013, 9, 503–509, doi:10.3762/bjoc.9.54

• activity [16][17][18][19][20][21][22], including hypoglycemic (1), anti-HIV (2), HIV-1 specific non-nucleoside reverse transcriptase inhibitor (3), sedative (4), and respiratory syncytial virus (RSV) inhibitory activity (5; Figure 1). A literature search revealed that the 1,2,4-benzothiadiazine 1,1

Asymmetric synthesis of host-directed inhibitors of myxoviruses

• Terry W. Moore,
• Kasinath Sana,
• Dan Yan,
• Pahk Thepchatri,
• John M. Ndungu,
• Manohar T. Saindane,
• Mark A. Lockwood,
• Michael G. Natchus,
• Dennis C. Liotta,
• Richard K. Plemper,
• James P. Snyder and
• Aiming Sun

Beilstein J. Org. Chem. 2013, 9, 197–203, doi:10.3762/bjoc.9.23

• syncytial virus (RSV), measles virus (MeV), human parainfluenza virus (HPIV) and others [1]. Because myxoviruses are responsible for the majority of human morbidity and mortality cases due to viral respiratory illness globally, a therapeutic strategy that targets these viruses could have a substantial

• : asymmetric synthesis; benzimidazole; host-directed; myxovirus; small molecule inhibitor; Introduction Myxoviruses are divided into two evolutionarily distinct yet related families: the orthomyxoviridae, which is composed largely of the influenza viruses, and the paramyxoviridae, which includes respiratory

Marilones A–C, phthalides from the sponge-derived fungus Stachylidium sp.

• Celso Almeida,
• Stefan Kehraus,
• Miguel Prudêncio and
• Gabriele M. König

Beilstein J. Org. Chem. 2011, 7, 1636–1642, doi:10.3762/bjoc.7.192

• Kumaki et al. [27], the Herpes Simplex Virus-2 (HSV-2) activity assays according to Harden et al. [28], the Respiratory Syncytial virus (RSV) activity assays according to Barnard et al. [29][30], the Influenza viruses A and B (Flu A and B) activity assays as described by Sidwell and Smee [31], and the